XL 188 ( XL-188;XL188 )

Catalog No. M17000 CAS No.

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

XL 188
Note

Research use only, not for human use.
Brief Description

XL188 (XL-188) is a potent, selective, non-covalent active-site inhibitor of USP7 with IC50 of 90 nM and 193 nM for USP7 full length enzyme and catalytic domain, respectively.
Description

XL188 (XL-188) is a potent, selective, non-covalent active-site inhibitor of USP7 with IC50 of 90 nM and 193 nM for USP7 full length enzyme and catalytic domain, respectively; exhibits little to no inhibition against a panel of 41 DUBs; promotes USP7-dependent loss of HDM2 and increases p53 and p21, significantly blocks labeling of USP7 by HA-Ub-Vs with an IC50 of 0.9 uM; a probe suitable for in vivo studies, highly valuable for pharmacological validation of USP7 in animal disease models.
Synonyms

XL-188;XL188
Pathway

Proteasome/Ubiquitin
Target

DUB
Recptor

DUB
Research Area

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Indication

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CAS Number

--
Formula Weight

574.73
Molecular Formula

C32H42N6O4
Purity

>98% (HPLC)
Solubility

——
SMILES

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Chemical Name

(R)-N-(3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-4-oxo-3,4-dihydroquinazolin-7-yl)-3-(4-methylpiperazin-1-yl)propanamide

1. Lamberto I, et al. Cell Chem Biol. 2017 Sep 28. pii: S2451-9456(17)30329-X.

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